Pain medication and long QT syndrome

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Pain medication and long QT syndrome

Long QT syndrome is a cardiac repolarization disorder and is associated with an increased risk of torsades de pointes. The acquired form is most often attributable to administration of specific medications and/or electrolyte imbalance. This review provides insights into the risk for QT prolongation associated with drugs frequently used in the treatment of chronic pain. In the field of pain medi...

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KCNE1 and KCNE2 variants in Patients with Long QT Syndrome

Introduction: Long QT syndrome (LQTS) is a type of ventricular arrhythmia characterized by prolonged QT intervals on electrocardiogram or delay in ventricular repolarization and it can lead to syncope, seizure and sudden cardiac death. Here, KCNE1 and KCNE2 variants are studied among Iranian affected families with this syndrome. Materials and Methods: Fifty patients referring to Rajaei Cardiov...

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Long QT Syndrome

Background. Erythromycin is known to prolong ventricular repolarization and has been associated with the occurrence of torsades de pointes. In this study, we have investigated potential mechanisms in vivo and in vitro for induction of an acquired long QT syndrome by erythromycin. Methods and Results. Ventricular electrograms and endocardial monophasic action potentials were recorded in anesthet...

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The Long QT Syndrome

Introduction The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited LQTS is the prototype of the "primary cardiac arrhythmias" or "cardiac ion channelopathies". The study of inherited LQTS has prov...

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Long Qt Syndrome

Department of Biology, National Taiwan Normal University, Taipei; Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taipei; Department of Internal Medicine, Wei Gong Memorial Hospital, Tou Fen, Miaoli; Division of Cardiology, Department of Medicine, Veterans General Hospital-Taipei; and Department of Medical Research and Education, Veterans General Hospita...

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ژورنال

عنوان ژورنال: The Korean Journal of Pain

سال: 2018

ISSN: 2005-9159,2093-0569

DOI: 10.3344/kjp.2018.31.1.3